This article explains, in educational terms, catheter-directed thrombolysis — how the technology works and where it fits. Deep vein thrombosis is the formation of a blood clot within the deep veins, most often in the legs, and it can cause pain, swelling, and — if a fragment travels to the lungs — pulmonary embolism. As a medical device manufacturer, INVAMED develops technologies in this area; the information here is educational and not medical advice.
Background: Deep Vein Thrombosis (DVT)
Whether an interventional approach is appropriate is a clinical decision that weighs clot age, location, bleeding risk, and overall condition. Standard care starts with anticoagulation (blood thinners), but selected patients with large, symptomatic, or limb-threatening clot burden may be considered for catheter-based clot removal. Endovascular thrombus removal aims to restore venous flow quickly and, in appropriate cases, to reduce the risk of post-thrombotic syndrome.
Catheter-Directed Thrombolysis (CDT)
Catheter-directed thrombolysis delivers a clot-dissolving drug directly into the thrombus through a multi-side-hole infusion catheter. Targeted delivery concentrates the drug where it is needed and can reduce systemic exposure compared with intravenous thrombolysis. INVAMED's Viper ULTRA thrombolysis catheter is designed for this localized infusion role. CDT is typically reserved for selected patients after careful bleeding-risk evaluation.
Design and Technical Notes
INVAMED's Mantis platform is organized by the mechanism used to engage and remove venous clot, alongside protective and access tools. Large-bore aspiration requires appropriately sized access and attention to blood-loss management. Manufacturer performance descriptions reflect device design goals rather than guaranteed individual outcomes.
Key Considerations
- Manufacturer performance descriptions reflect device design goals rather than guaranteed individual outcomes.
- All INVAMED thrombectomy devices are for use by trained interventionalists under imaging guidance and per the IFU.
- Retrievable IVC filters are intended to be removed once protection is no longer needed, per current guidance.
Frequently Asked Questions
What is the Mantis platform?
Mantis is INVAMED's thrombectomy family, offering rotational (Mantis PRO, Mantis CURVE), aspiration (Mantis AspireJET, Dovi), and fistula-specific (Mantis XP) options.
Can thrombectomy be done in one session?
Mechanical thrombectomy is often designed to restore flow in a single session where feasible, but this depends on the clot and is judged by the operator.
What is the regulatory status of these devices?
Device availability and regulatory status vary by country. Please contact INVAMED or your authorized local distributor for current regulatory information applicable to your region.
About INVAMED
INVAMED operates a dedicated R&D center (INVAcenter) focused on minimally invasive device development. INVAMED is a medical device manufacturer headquartered in Ankara, Turkey, founded in 2005.
Clinical and Technical Context
Deep vein thrombosis is the formation of a blood clot within the deep veins, most often in the legs, and it can cause pain, swelling, and — if a fragment travels to the lungs — pulmonary embolism. Standard care starts with anticoagulation (blood thinners), but selected patients with large, symptomatic, or limb-threatening clot burden may be considered for catheter-based clot removal. Whether an interventional approach is appropriate is a clinical decision that weighs clot age, location, bleeding risk, and overall condition. INVAMED's Mantis XP is positioned specifically for fistula thrombectomy. Left untreated, extensive iliofemoral DVT is associated with a higher risk of long-term complications such as post-thrombotic syndrome, marked by chronic swelling and discomfort. Techniques include mechanical thrombectomy, aspiration thrombectomy, and pharmacomechanical approaches that combine device action with a clot-dissolving drug. Retrievable filters are intended to avoid the long-term risks associated with permanently implanted filters. All INVAMED thrombectomy devices are for use by trained interventionalists under imaging guidance and per the IFU. INVAMED's Mantis PRO combines rotational clot disruption with ultra-aspiration in one platform, according to the company. INVAMED's MultiBEAM is a retrievable IVC filter, meaning it is designed to be removed once the risk period passes. Any use of thrombolytic drugs demands careful bleeding-risk assessment by the clinician. Access salvage decisions are made by the vascular access team based on the specific circuit.
Related on INVAMED
- Deep Vein Thrombosis (DVT) — product category
- Mantis Directional Thrombectomy System — Technical Overview
- How long is recovery after venous thrombectomy?
- Rotational Thrombectomy: How It Works and Why It Matters
Important Disclaimer
This content is educational and technical in nature and must not be interpreted as medical advice or as a promise of any clinical outcome. Individual results depend on many factors and can only be evaluated by a treating physician. Figures attributed to INVAMED reflect manufacturer or published data and are not a guarantee of results. All INVAMED devices are to be used by trained clinicians per the approved IFU, and availability is subject to local regulatory status.
Reviewed by the INVAMED Medical Affairs team. Content is educational and technical in nature.