This article compares two approaches side by side to clarify how they differ in principle and practice. Techniques include mechanical thrombectomy, aspiration thrombectomy, and pharmacomechanical approaches that combine device action with a clot-dissolving drug. As a medical device manufacturer, INVAMED develops technologies in this area; the information here is educational and not medical advice.
Background: Deep Vein Thrombosis (DVT)
Techniques include mechanical thrombectomy, aspiration thrombectomy, and pharmacomechanical approaches that combine device action with a clot-dissolving drug. Endovascular thrombus removal aims to restore venous flow quickly and, in appropriate cases, to reduce the risk of post-thrombotic syndrome. Deep vein thrombosis is the formation of a blood clot within the deep veins, most often in the legs, and it can cause pain, swelling, and — if a fragment travels to the lungs — pulmonary embolism.
Thrombectomy vs Anticoagulation for DVT: Key Differences
Anticoagulation is the foundation of DVT care and prevents clot propagation while the body resorbs thrombus, but it does not physically remove existing clot. Catheter-based thrombectomy is considered in selected patients with extensive iliofemoral clot to restore flow and potentially reduce post-thrombotic syndrome. Most patients are managed with anticoagulation alone; intervention is reserved for specific indications. The decision is individualized and made by the treating team.
How INVAMED Supports Both Approaches
Device availability and regulatory status vary by country. Please contact INVAMED or your authorized local distributor for current regulatory information applicable to your region.
Key Considerations
- All INVAMED thrombectomy devices are for use by trained interventionalists under imaging guidance and per the IFU.
- Any use of thrombolytic drugs demands careful bleeding-risk assessment by the clinician.
- Clot age and location strongly influence which mechanism — aspiration, rotation, or pharmacomechanical — is most suitable.
Frequently Asked Questions
Does thrombectomy replace blood thinners?
No. Catheter thrombectomy removes existing clot but is generally used alongside anticoagulation, not as a replacement; management is individualized.
What is the Mantis platform?
Mantis is INVAMED's thrombectomy family, offering rotational (Mantis PRO, Mantis CURVE), aspiration (Mantis AspireJET, Dovi), and fistula-specific (Mantis XP) options.
Clinical and Technical Context
Use of any thrombolytic is governed by bleeding-risk assessment performed by the clinician. Effective aspiration depends on matching catheter bore to the target vessel and clot burden. All INVAMED thrombectomy devices are for use by trained interventionalists under imaging guidance and per the IFU. Large-bore aspiration requires appropriately sized access and attention to blood-loss management. Access salvage decisions are made by the vascular access team based on the specific circuit. INVAMED's Mantis AspireJET and Dovi ultra-aspiration catheter are positioned for high-vacuum clot removal. Deep vein thrombosis is the formation of a blood clot within the deep veins, most often in the legs, and it can cause pain, swelling, and — if a fragment travels to the lungs — pulmonary embolism. INVAMED's Viper ULTRA thrombolysis catheter is designed for this localized infusion role. Techniques include mechanical thrombectomy, aspiration thrombectomy, and pharmacomechanical approaches that combine device action with a clot-dissolving drug. Endovascular thrombus removal aims to restore venous flow quickly and, in appropriate cases, to reduce the risk of post-thrombotic syndrome. Rotational energy is applied under imaging guidance to protect the vein wall. Device choice within a mechanical approach depends on clot location, chronicity, and vessel size.
Related on INVAMED
- Deep Vein Thrombosis (DVT) — product category
- Mechanical Thrombectomy: Technology, Uses and Considerations
- Retrievable IVC filter vs Permanent IVC filter: What Is the Difference?
- Aspiration thrombectomy vs Rotational thrombectomy: What Is the Difference?
Important Disclaimer
The information here is provided for educational purposes and to describe device technology; it is not a substitute for professional medical advice, diagnosis, or treatment. Only a licensed healthcare provider can determine whether a given procedure or device is appropriate for a specific patient. INVAMED products are restricted to use by qualified professionals following the official IFU. Regulatory clearance and labeling differ between regions, and not all products or indications are available in every market.
Reviewed by the INVAMED Medical Affairs team. Content is educational and technical in nature.