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INVAMED

Over-the-wire rotational pharmacomechanical thrombectomy system combining clot disruption with lytic delivery for large-burden DVT.

Last Updated: July 2026

Mantis CURVE Over-the-Wire (OTW) Rotational Pharmacomechanical Thrombectomy System

Mantis CURVE Over-the-Wire (OTW) Rotational Pharmacomechanical Thrombectomy System

An over-the-wire (OTW) device merging rotational disruption with pharmacologic lysis, effectively clearing large thrombi while protecting healthy vessel walls.

Specialties

Venous

Rotational Pharmacomechanical Thrombectomy

  • Venturi Effect Mechanism: As the active tip spins within the vessel lumen, a hydrodynamic vortex forms, enabling targeted fragmentation and aspiration of the thrombus.

  • Drug Infusion Port: Concurrent infusion of anti-thrombolytic agents ensures cohesive mixing with the thrombus, expediting clot dissolution and clearance.

Active Tip with Coil & Sinusoidal Wave

  • Coil Design: The sinusoidal wave geometry, visible from the distal tip to proximal region, efficiently engages and fragments clot.

  • Preventing Distal Embolism: The rotational vortex action, combined with controlled drug release, helps retain clot particles in proximity for prompt removal, reducing the risk of distal migration.

Over-the-Wire (OTW) Catheter System

  • 0.035” Guidewire Compatibility: Simplifies wire management in complex anatomies (including tortuous or large-diameter vessels).

  • Catheter Lengths: With 90 cm and 110 cm functional lengths, and 120 cm or 135 cm profiles, the system accommodates an array of procedural approaches.

Multiple Catheter Profiles & Radiopacity

  • 5.0F to 8.0F: Offers suitable sizing for broad vessel diameters in the peripheral venous circulation, pulmonary artery, or IVC.

  • Radiopaque: The braided shaft is visible under fluoroscopy from distal tip to proximal segment, aiding real-time device positioning.

PTFE Inner Lining

  • Low-Friction Catheter Lumen: Streamlines guidewire passage and drug infusion, helping avoid clot or tissue adherence to the catheter walls.

  • Reduced Shear Stress: Minimizes friction on vessel endothelium, supporting safer navigation in high-stakes procedures.

  • Venturi Effect Mechanism: As the active tip spins within the vessel lumen, a hydrodynamic vortex forms, enabling targeted fragmentation and aspiration of the thrombus.

  • Drug Infusion Port: Concurrent infusion of anti-thrombolytic agents ensures cohesive mixing with the thrombus, expediting clot dissolution and clearance.

  • Coil Design: The sinusoidal wave geometry, visible from the distal tip to proximal region, efficiently engages and fragments clot.

  • Preventing Distal Embolism: The rotational vortex action, combined with controlled drug release, helps retain clot particles in proximity for prompt removal, reducing the risk of distal migration.

  • 0.035” Guidewire Compatibility: Simplifies wire management in complex anatomies (including tortuous or large-diameter vessels).

  • Catheter Lengths: With 90 cm and 110 cm functional lengths, and 120 cm or 135 cm profiles, the system accommodates an array of procedural approaches.

  • 5.0F to 8.0F: Offers suitable sizing for broad vessel diameters in the peripheral venous circulation, pulmonary artery, or IVC.

  • Radiopaque: The braided shaft is visible under fluoroscopy from distal tip to proximal segment, aiding real-time device positioning.

  • Low-Friction Catheter Lumen: Streamlines guidewire passage and drug infusion, helping avoid clot or tissue adherence to the catheter walls.

  • Reduced Shear Stress: Minimizes friction on vessel endothelium, supporting safer navigation in high-stakes procedures.