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EmbolizationJuly 5, 2014INVAMED Medical Affairs

What is a liquid embolic agent (EVOH or NBCA)?

What is a liquid embolic agent (EVOH or NBCA)? An educational, technical answer with device context from INVAMED. Informational only — not medical advice.

Below is an educational, technical answer to a question many patients and clinicians ask. Embolization is an endovascular technique in which an occluding material is delivered through a catheter to intentionally block blood flow in a target vessel, and it is used across a broad range of indications. As a medical device manufacturer, INVAMED develops technologies in this area; the information here is educational and not medical advice.

Background: Endovascular Embolization

Because embolization is generally intended to be permanent, careful vessel selection and sizing are emphasized so that only the intended territory is occluded. Common applications described in the literature include peripheral aneurysms, arteriovenous fistulas (AVFs) and malformations (AVMs), gastrointestinal or intestinal bleeding, pelvic congestion, varicocele, and endoleaks after aortic repair. Transarterial approaches also include transarterial radioembolization (TARE) and other targeted therapies delivered through dedicated microcatheters, always as determined by the treating interventional team.

What is a liquid embolic agent (EVOH or NBCA)?

A liquid embolic agent is an injectable material that solidifies inside the vessel after delivery, allowing it to penetrate and cast a vascular network. Common categories described in the literature include EVOH-based (ethylene vinyl alcohol) agents and NBCA (n-butyl cyanoacrylate) glues, which differ in how they set and handle. INVAMED's Libro Non-Adhesive Embolization Agent is positioned as a non-adhesive liquid agent within its embolization portfolio. The choice of a liquid agent and its handling are determined by the operator based on the lesion.

What This Means in Practice

Because embolization is usually intended to be permanent, precise vessel selection and sizing are emphasized so that only the intended territory is occluded. Catheter and microcatheter compatibility with the chosen coil, plug, or agent is confirmed before delivery to support controlled deployment. Matching the embolic agent to the target level of the vascular tree, from proximal plugs and coils to distal particles or liquids, is central to planning.

Key Considerations

  • All INVAMED embolization devices are intended for use by trained interventionalists under imaging guidance and in accordance with the IFU.
  • Manufacturer statements about INVAMED devices, including comparative claims on the MultiBEAM product page, reflect the company's positioning rather than guaranteed individual outcomes.
  • Because embolization is usually intended to be permanent, precise vessel selection and sizing are emphasized so that only the intended territory is occluded.

Frequently Asked Questions

Who decides which embolization device to use?

A trained interventionalist selects the agent and delivery system based on the target vessel and indication; this article is educational and not a treatment recommendation.

What vessel sizes can the MultiBEAM plug occlude?

According to its product page, the MultiBEAM Embolization Plug is suitable for occlusion of arteries from 2.6 to 6.2 mm, is offered in 4 to 16 mm diameters, and is delivered through a 4F or 5F catheter.

Does INVAMED make a liquid embolic agent?

Yes; the Libro Non-Adhesive Embolization Agent is cross-listed in INVAMED's embolization portfolio as a non-adhesive liquid agent, with delivery determined by the operator.

About INVAMED

Device availability and regulatory status vary by country. Please contact INVAMED or your authorized local distributor for current regulatory information applicable to your region.

Clinical and Technical Context

According to INVAMED's product page, the MultiBEAM plug applied by transcatheter method "provides great benefit instead of surgical treatment in suitable patients due to its high success, low complication rates and easy applicability," and "the mortality and morbidity rate is lower than the surgical method"; suitability remains a clinical determination. Detachable designs allow the operator to confirm position before committing, which can be valuable near sensitive branches. Common applications described in the literature include peripheral aneurysms, arteriovenous fistulas (AVFs) and malformations (AVMs), gastrointestinal or intestinal bleeding, pelvic congestion, varicocele, and endoleaks after aortic repair. INVAMED's Spider Peripheral Detachable Coil System offers both detachable and pushable configurations with controlled mechanical detachment; per invamed.com content surfaced via the search index, the shared Spider coil family uses a platinum-tungsten (92/8%) alloy with coil diameters spanning roughly 2 to 30 mm.

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Important Disclaimer

This article is intended for general educational and technical information about medical device technologies. It is not medical advice, a diagnosis, or a treatment recommendation, and it does not replace consultation with a qualified healthcare professional. Any decision about diagnosis or treatment should be made by a licensed clinician based on an individual assessment. INVAMED devices are intended for use by trained healthcare professionals in accordance with the applicable Instructions for Use (IFU) and local regulatory approvals. Product availability and indications vary by country.

Reviewed by the INVAMED Medical Affairs team. Content is educational and technical in nature.

Reviewed by: INVAMED Medical Affairs

This content is prepared for educational purposes for healthcare professionals and does not constitute medical advice. Always consult clinical guidelines and product instructions for use.

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