Comparing Mantis vs Viper highlights two distinct engineering philosophies within INVAMED's DVT portfolio: rotational pharmacomechanical thrombectomy versus ultrasonic-assisted pharmacologic thrombolysis. This overview is intended to help clinicians understand how each platform is designed, not to suggest one is universally superior.
What Is the Core Design Difference?
Mantis is built around a rotating leaf-tip mechanism that mechanically fragments thrombus, paired with an aspiration lumen and pharmacomechanical compatibility. Viper, by contrast, is built around ultrasonic energy paired with thrombolytic infusion through a multi-hole catheter, without a rotating mechanical fragmentation element. Both platforms are designed to address thrombus in the venous system, but through fundamentally different mechanisms.
How Do the Two Platforms Compare?
| Feature | Mantis Platform | Viper System |
|---|---|---|
| Primary mechanism | Rotational mechanical fragmentation + aspiration | Ultrasonic energy + thrombolytic infusion |
| Medication role | Optional, pharmacomechanical capability | Central to the treatment mechanism |
| Aspiration | Integrated aspiration lumen (notably in Mantis PRO) | Not a primary design feature |
| Catheter configuration | Rotational drive shaft with leaf tip | Over-the-wire, multi-hole infusion catheter |
| Available lengths | Varies by Mantis variant | 90, 135, 150, and 200 cm |
This comparison reflects general design characteristics; clinicians should consult the current Instructions for Use (IFU) for each device for complete specifications.
When Might Each Approach Be Considered?
Mantis-family devices may be considered when mechanical clot fragmentation and aspiration are a priority, such as with more organized or bulky thrombus where physical clearance is desired alongside optional pharmacologic support. Viper may be considered when a primarily pharmacologic strategy is preferred but ultrasonic assistance is desired to enhance thrombolytic penetration and potentially support lower overall drug dosing. Some centers may use different devices for different clot presentations within the same practice.
Can These Approaches Be Used in the Same Patient Population?
Both platforms are part of INVAMED's broader DVT portfolio and are intended for physicians managing venous thromboembolic disease. The choice between a predominantly mechanical, predominantly ultrasonic-pharmacologic, or staged multi-device approach depends on clot chronicity, extent, bleeding risk, and institutional protocols. All decisions regarding device selection and technique are made by the treating physician based on individualized patient assessment.
Frequently Asked Questions
Does Viper have a mechanical fragmentation component like Mantis?
No. Viper's design centers on ultrasonic energy combined with thrombolytic infusion, rather than a rotating mechanical element. Its mechanism differs fundamentally from the rotational approach used in the Mantis platform.
Can Mantis be used without any thrombolytic medication?
Mantis is designed to support mechanical disruption and aspiration independently, with pharmacomechanical capability available when clinically indicated. Use with or without adjunctive medication is determined by the treating physician.
What is the regulatory status of these devices?
Device availability and regulatory status vary by country. Please contact INVAMED or your authorized local distributor for current regulatory information applicable to your region.
Related INVAMED Resources
- Deep Vein Thrombosis (DVT) Product Portfolio
- Pulmonary Embolism Management
- Request Information from INVAMED
Medical Disclaimer: This article is provided for general informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment recommendation. It is not a substitute for consultation with a qualified healthcare professional. Product indications, availability, and regulatory status vary by country. Always refer to the official Instructions for Use (IFU) and consult a licensed physician for guidance specific to your situation. INVAMED devices are intended for use by trained healthcare professionals.