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Neurovascular InterventionsJune 22, 2008INVAMED Medical Affairs

Mechanical thrombectomy or Thrombolysis alone (tPA)? A Technical Comparison

Mechanical thrombectomy vs Thrombolysis alone (tPA): a balanced, educational comparison of how each works, their trade-offs, and how INVAMED supports both…

This article compares two approaches side by side to clarify how they differ in principle and practice. Intracranial aneurysms are focal outpouchings of a brain artery wall, and endovascular options aim to seal the aneurysm from circulation to reduce rupture risk. As a medical device manufacturer, INVAMED develops technologies in this area; the information here is educational and not medical advice.

Background: Acute Ischemic Stroke and Intracranial Aneurysm Intervention

Aneurysm techniques include packing the sac with detachable coils and redirecting flow across the neck with a densely braided flow diverter so the sac thromboses over time. Acute ischemic stroke from a large vessel occlusion happens when a clot blocks a major brain artery, cutting off blood flow to a region of brain tissue. Intracranial aneurysms are focal outpouchings of a brain artery wall, and endovascular options aim to seal the aneurysm from circulation to reduce rupture risk.

Mechanical thrombectomy vs Thrombolysis alone (tPA): Key Differences

Mechanical thrombectomy physically removes a large-vessel clot, whereas intravenous thrombolysis relies on a drug to dissolve it. For eligible large-vessel occlusions, thrombectomy can achieve more complete reperfusion, and the two are frequently used together where indicated. Thrombolysis has time and eligibility constraints and does not reliably clear large proximal clots on its own. The stroke team determines the role of each based on occlusion site, timing, and imaging.

How INVAMED Supports Both Approaches

INVAMED's neurovascular portfolio spans clot retrieval, aspiration, aneurysm packing, embolization, and the access tools that reach the intracranial circulation. Per INVAMED, the Spider coils use a platinum-tungsten 92/8 percent alloy across 2 to 30 mm diameters, and the Libro agent uses EVOH with DMSO and tantalum in multiple viscosity formulas including 6 and 8 percent concentrations. Device sizes, coil diameter ranges, and catheter compatibilities are detailed in product documentation, and buyers should confirm local registration and indication status.

Key Considerations

  • Speed to reperfusion is a central factor in stroke thrombectomy, which shapes device readiness and workflow in eligible patients.
  • Clot characteristics and vessel tortuosity influence whether a stent retriever, aspiration, or combined technique is chosen.
  • All INVAMED neurovascular devices are intended for use by trained neurointerventional operators under imaging guidance and per the IFU.

Frequently Asked Questions

Who determines eligibility for thrombectomy?

The treating stroke team determines eligibility using imaging and current criteria; this article is educational and not medical advice.

Are these neurovascular devices CE marked?

Device availability and regulatory status vary by country. Please contact INVAMED or your authorized local distributor for current regulatory information applicable to your region.

What treatment window does INVAMED cite for the KinG device?

According to INVAMED product content, the KinG device is described as capturing and extracting cerebral artery clots within a treatment window of up to 24 hours; eligibility is a clinical determination.

Clinical and Technical Context

INVAMED's KinG Intracranial Revascularization Device is a self-expanding nitinol stent retriever with platinum markers at the proximal and distal ends of the basket for fluoroscopic visualization, intended for vessels including the internal carotid, middle and anterior cerebral, and basilar and vertebral arteries. INVAMED's Mantis Directional Thrombectomy System and AngioHAND Thrombus Removal System are positioned for aspiration-based clot removal in this setting. The choice of aspiration, a stent retriever, or a combined approach is made by the operator based on clot and vessel characteristics. All INVAMED neurovascular devices are intended for use by trained neurointerventional operators under imaging guidance and per the IFU. Patient eligibility, the treatment window, and device selection are all determined by the treating neurointerventional team using imaging and current criteria. Whether thrombectomy is indicated depends on occlusion location, time from onset, and imaging, as judged by the stroke team. Agent concentration and injection technique are selected by the operator for the target lesion. Manufacturer statements, including the described up-to-24-hour window for the KinG device, reflect product content and do not establish individual eligibility.

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Important Disclaimer

The information here is provided for educational purposes and to describe device technology; it is not a substitute for professional medical advice, diagnosis, or treatment. Only a licensed healthcare provider can determine whether a given procedure or device is appropriate for a specific patient. INVAMED products are restricted to use by qualified professionals following the official IFU. Regulatory clearance and labeling differ between regions, and not all products or indications are available in every market.

Reviewed by the INVAMED Medical Affairs team. Content is educational and technical in nature.

Reviewed by: INVAMED Medical Affairs

This content is prepared for educational purposes for healthcare professionals and does not constitute medical advice. Always consult clinical guidelines and product instructions for use.

Mechanical thrombectomy vs Thrombolysis alone (tPA)mechanical thrombectomy strokestent retrieverstroke clot retrieval proceduretime windowsuccess raterecanalization rate (TICI)
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