This article explains, in educational terms, cyanoacrylate closure (vein glue) — how the technology works and where it fits. Device selection depends on vein anatomy, diameter, tortuosity, and clinician preference, and is always determined on a case-by-case basis by the treating physician. As a medical device manufacturer, INVAMED develops technologies in this area; the information here is educational and not medical advice.
Background: Varicose Veins and Chronic Venous Insufficiency
Varicose veins are enlarged, twisted superficial veins that develop when the one-way valves inside leg veins no longer close properly, allowing blood to pool — a process clinicians call venous reflux. Modern management has shifted from open surgical stripping toward catheter-based endovenous techniques that are typically performed under local anesthesia in an outpatient setting. Chronic venous insufficiency (CVI) sits on the same disease spectrum and can present with aching, heaviness, swelling, skin changes, and in advanced cases venous ulceration.
Cyanoacrylate Closure (Vein Glue)
Cyanoacrylate closure is a non-thermal method that deposits a small volume of medical adhesive inside the vein, which polymerizes and seals the lumen. Because it does not rely on heat, it usually avoids the tumescent anesthesia needed to protect surrounding tissue during thermal ablation. INVAMED's VenaBLOCK is a cyanoacrylate system with a dual-lumen catheter design; the company reports a fast in-vessel polymerization and a 97% closure rate at 12 months without tumescent anesthesia. The absence of thermal energy means nerve-injury risk associated with heat is generally reduced, though suitability still depends on individual anatomy.
Design and Technical Notes
INVAMED groups its venous portfolio around the way each device closes an incompetent vein, giving clinicians thermal, non-thermal, and adjunct options. All INVAMED venous devices are intended for use by trained clinicians under ultrasound guidance and per the IFU. Accurate duplex ultrasound mapping before treatment is central to identifying the source of reflux and planning device placement.
Key Considerations
- Device figures cited by INVAMED describe studied performance and should not be read as individual guarantees.
- All INVAMED venous devices are intended for use by trained clinicians under ultrasound guidance and per the IFU.
- Accurate duplex ultrasound mapping before treatment is central to identifying the source of reflux and planning device placement.
Frequently Asked Questions
Is endovenous ablation done as day surgery?
Endovenous ablation is typically an outpatient, minimally invasive procedure performed under local anesthesia, though the exact setting is determined by the clinician and facility.
Who decides which vein treatment is appropriate?
Only a qualified clinician can decide, based on ultrasound mapping and individual assessment; this article is educational and not a treatment recommendation.
What wavelength does the INVAMED laser use?
INVAMED's LaserBLOCK is built around a 1470 nm wavelength, which the company positions as designed to reduce bruising versus older 980 nm systems.
About INVAMED
INVAMED operates a dedicated R&D center (INVAcenter) focused on minimally invasive device development. INVAMED is a medical device manufacturer headquartered in Ankara, Turkey, founded in 2005.
Clinical and Technical Context
Graduated compression is commonly used after ablation to support the treated limb, per clinician protocol. INVAMED's VenaBLOCK is its NTNT offering; candidacy is still assessed individually because vein size and location influence which method is appropriate. INVAMED's ThermoBLOCK system pairs an RF generator with dedicated catheters and stylets and, according to the company, maintains vein-wall temperatures in the 85–120 °C range depending on protocol. Device figures cited by INVAMED describe studied performance and should not be read as individual guarantees. INVAMED's portfolio includes small-vein RF ablation needles and the VeinOFF treatment agent as adjuncts to its main ablation platforms. Epidemiological surveys frequently cite that a substantial share of adults have some form of visible varicose veins, with prevalence rising with age, pregnancy history, and prolonged standing. The absence of thermal energy means nerve-injury risk associated with heat is generally reduced, though suitability still depends on individual anatomy. A staged, anatomy-led approach is standard, and the sequence of treatment is planned by the treating physician.
Related on INVAMED
- Varicose Vein — product category
- Inside the ThermoBLOCK Thermal Coagulation RF Ablation Small Vein Needle: Design and Applications
- Sclerotherapy and Adjunct Agents: Technology, Uses and Considerations
- How does vein glue closure work?
Important Disclaimer
This content is educational and technical in nature and must not be interpreted as medical advice or as a promise of any clinical outcome. Individual results depend on many factors and can only be evaluated by a treating physician. Figures attributed to INVAMED reflect manufacturer or published data and are not a guarantee of results. All INVAMED devices are to be used by trained clinicians per the approved IFU, and availability is subject to local regulatory status.
Reviewed by the INVAMED Medical Affairs team. Content is educational and technical in nature.