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INVAMED

SCIENCE & PUBLICATIONS

Clinical Evidence Library

Peer-reviewed studies, registries, and publications evaluating INVAMED technologies — presented with verified data only, linked to their original sources.

Clinical evidence is the foundation of responsible medical technology. INVAMED supports independent, peer-reviewed research evaluating the safety and effectiveness of its technologies, and works with clinical investigators worldwide to expand the evidence base for minimally invasive care.

Selected peer-reviewed publications

VenaBlock venous closure system

  • Comparative analysis of VenaBlock and VenaSeal systems for catheter-guided endovenous cyanoacrylate closure in treating chronic venous insufficiency of the lower extremity: effectiveness and feasibility.
    International Angiology. doi:10.23736/S0392-9590.24.05143-5
    A systematic comparison including 1,882 extremities from 11 VenaBlock studies, reporting cumulative recanalization-free survival at 6 to 60 months and improvements in venous clinical severity and quality-of-life scores.
  • Registry to investigate the efficacy and safety of the VenaBlock vein sealing system for varicose veins in Singapore — six-month results of the RIVIERA trial.
    Linn YL, Yap CJQ, Soon SXY, et al. Phlebology. 2021;36(10):816-826. doi:10.1177/02683555211025181
    A prospective registry evaluating procedural success, closure rates, and safety outcomes of cyanoacrylate closure in an Asian patient population.

Our approach to evidence

INVAMED views post-market clinical follow-up and investigator-initiated research as continuous obligations, not one-time milestones. The company supports registry participation, comparative studies, and long-term outcome reporting across its vascular, orthopedic, and surgical portfolios, and makes study information available to healthcare professionals on request.

For investigators

Clinicians and research institutions interested in collaborative studies, registry participation, or access to technical documentation for research purposes can reach the INVAMED Medical Affairs team through our contact page.

Additional publications indexed on PubMed provide further independent evaluation of these technologies. This page is updated as new peer-reviewed data becomes available.

AllAortic AneurysmPeripheral Arterial DiseaseVaricose Veins / Chronic Venous InsufficiencyCase seriesProspective cohortProspective single-center trialRetrospective cohortReviewSystematic review
Systematic reviewVaricose Veins / Chronic Venous Insufficiency2024

Comparative analysis of VenaBlock and VenaSeal systems for endovenous cyanoacrylate closure in chronic venous insufficiency

Literature-based comparative effectiveness analysis of the two most widely used cyanoacrylate closure systems.

International Angiologyn = 2406Cumulative recanalization-free survival at 6-60 months; VCSS; quality-of-life scores

Across 1,882 extremities (11 VenaBlock studies) and 524 extremities (8 VenaSeal studies), cumulative recanalization-free survival was similar between systems (p=0.188); both significantly improved VCSS and QoL scores.

DOI VenaBLOCK Non-Thermal Treatment for Vein Disease & Varicose Veins

Every figure in this library is entered from a verifiable published source by the INVAMED Medical Affairs team. Entries awaiting source verification are marked and exclude all numeric data until confirmed. Device availability and regulatory status vary by country.