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INVAMED

SCIENCE & PUBLICATIONS

Clinical Evidence Library

Peer-reviewed studies, registries, and publications evaluating INVAMED technologies — presented with verified data only, linked to their original sources.

Clinical evidence is the foundation of responsible medical technology. INVAMED supports independent, peer-reviewed research evaluating the safety and effectiveness of its technologies, and works with clinical investigators worldwide to expand the evidence base for minimally invasive care.

Selected peer-reviewed publications

VenaBlock venous closure system

  • Comparative analysis of VenaBlock and VenaSeal systems for catheter-guided endovenous cyanoacrylate closure in treating chronic venous insufficiency of the lower extremity: effectiveness and feasibility.
    International Angiology. doi:10.23736/S0392-9590.24.05143-5
    A systematic comparison including 1,882 extremities from 11 VenaBlock studies, reporting cumulative recanalization-free survival at 6 to 60 months and improvements in venous clinical severity and quality-of-life scores.
  • Registry to investigate the efficacy and safety of the VenaBlock vein sealing system for varicose veins in Singapore — six-month results of the RIVIERA trial.
    Linn YL, Yap CJQ, Soon SXY, et al. Phlebology. 2021;36(10):816-826. doi:10.1177/02683555211025181
    A prospective registry evaluating procedural success, closure rates, and safety outcomes of cyanoacrylate closure in an Asian patient population.

Our approach to evidence

INVAMED views post-market clinical follow-up and investigator-initiated research as continuous obligations, not one-time milestones. The company supports registry participation, comparative studies, and long-term outcome reporting across its vascular, orthopedic, and surgical portfolios, and makes study information available to healthcare professionals on request.

For investigators

Clinicians and research institutions interested in collaborative studies, registry participation, or access to technical documentation for research purposes can reach the INVAMED Medical Affairs team through our contact page.

Additional publications indexed on PubMed provide further independent evaluation of these technologies. This page is updated as new peer-reviewed data becomes available.

AllAortic AneurysmPeripheral Arterial DiseaseVaricose Veins / Chronic Venous InsufficiencyCase seriesProspective cohortProspective single-center trialRetrospective cohortReviewSystematic review
Case seriesAortic Aneurysm2025

Multilayer flow modulator stents in aortic aneurysms: an overview based on preliminary experience with the Stena MFM

12 patients underwent aortic aneurysm repair with the Stena Multilayer Flow Modulator (July-December 2022) with 6-month CT angiography follow-up.

Cirugia y Cirujanosn = 12Technical success; aneurysm sac thrombosis; branch vessel patency; sac volume change at 6 months

Technical success 100% with no immediate re-intervention. Complete aneurysm sac thrombosis in all patients at 6 months with preserved main-lumen and branch patency; mean sac volume change -2.36%. No rupture, migration, retraction, thrombosis, or fracture observed.

DOI Stena Aortic Multi-Layer Flow ModulatorStena Multi-Layer Flow Modulator for Aortic Applications
ReviewAortic Aneurysm2024

Role of multilayer flow modulator stents in the treatment of arterial aneurysms

Narrative review of multilayer flow modulator technology for arterial aneurysms covering device rationale, hemodynamic mechanism, and published outcomes.

Therapeutic Advances in Cardiovascular DiseaseTechnical success; aneurysm thrombosis and shrinkage; branch vessel patency (across included studies)

Review of published MFM experience, including the Stena MFM, reporting favorable technical success, progressive aneurysm sac thrombosis, and side-branch patency compared with conventional EVAR limitations in branch preservation.

DOI Stena Aortic Multi-Layer Flow ModulatorStena Multi-Layer Flow Modulator for Peripheral

Every figure in this library is entered from a verifiable published source by the INVAMED Medical Affairs team. Entries awaiting source verification are marked and exclude all numeric data until confirmed. Device availability and regulatory status vary by country.