Minimally Invasive Fracture Fixation: Techniques, Technologies, and Clinical Outcomes
Introduction
The evolution of orthopedic trauma surgery has been marked by a progressive shift toward less invasive approaches that aim to minimize surgical trauma while achieving optimal fracture reduction and stable fixation. Minimally invasive fracture fixation (MIFF) represents a philosophical and technical paradigm shift from traditional open reduction and internal fixation (ORIF), prioritizing the preservation of biology alongside mechanical stability. This approach recognizes that successful fracture healing depends not only on stable fixation but also on maintaining the viability of bone fragments and surrounding soft tissues, preserving blood supply, and respecting the fracture hematoma as a source of healing factors and progenitor cells.
The development of minimally invasive techniques has been driven by an enhanced understanding of fracture biology, technological innovations in implant design and imaging, and clinical evidence demonstrating the potential benefits of biological fixation. These benefits include reduced surgical morbidity, decreased infection rates, faster healing times, and improved functional outcomes in appropriately selected cases. The spectrum of minimally invasive techniques encompasses percutaneous plating, intramedullary nailing, external fixation, and emerging technologies such as percutaneous fracture reduction tools and navigation systems.
Minimally invasive fracture fixation is not simply about making smaller incisions; it represents a comprehensive approach that begins with preoperative planning, incorporates specialized reduction techniques and implant systems, and requires a thorough understanding of indirect reduction principles. The successful application of these techniques demands a different skill set from traditional open approaches, including proficiency with fluoroscopic imaging, familiarity with specialized instrumentation, and the ability to achieve reduction without direct visualization of the fracture.
While minimally invasive techniques offer significant advantages in many fracture scenarios, they are not universally applicable. The appropriate selection of cases, understanding of limitations, and recognition of situations where more traditional approaches may be preferable are essential for optimizing outcomes. Additionally, the learning curve associated with these techniques presents challenges for training and implementation.
This comprehensive review examines the principles, techniques, technologies, and clinical applications of minimally invasive fracture fixation across different anatomical regions. By understanding both the advantages and limitations of these approaches, surgeons can make informed decisions to optimize outcomes for patients with fractures, balancing biological preservation with mechanical stability requirements.
Medical Disclaimer: This article is intended for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. The information provided should not be used for diagnosing or treating a health problem or disease. Invamed, as a medical device manufacturer, provides this content to enhance understanding of medical technologies. Always seek the advice of a qualified healthcare provider with any questions regarding medical conditions or treatments.
Principles and Evolution of Minimally Invasive Fracture Fixation
Historical Development
- Early Concepts and Pioneers:
- Gerhard Küntscher’s introduction of intramedullary nailing (1940s)
- Closed reduction and percutaneous fixation of articular fractures
- Limited approaches for specific fracture patterns
-
Early challenges with visualization and reduction
-
Biological Internal Fixation Concept:
- Stephan Perren and the AO group’s evolution from absolute stability to relative stability concepts
- Recognition of the importance of preserving blood supply
- Development of bridge plating techniques
-
Shift from anatomic reduction to functional reduction for certain fracture patterns
-
Technological Enablers:
- Improved fluoroscopic imaging capabilities
- Development of specialized instrumentation
- Evolution of implant design (locking plates, anatomic precontoured plates)
- Introduction of navigation and 3D imaging technologies
-
Specialized reduction tools for percutaneous use
-
Modern Evolution and Acceptance:
- Evidence-based validation of biological advantages
- Refinement of techniques for specific fracture patterns
- Integration into standard practice for many fracture types
- Development of formal training programs and curricula
- Continued technological innovation expanding applications
Fundamental Principles
- Biological Preservation:
- Maintenance of fracture hematoma as a source of growth factors and progenitor cells
- Preservation of periosteal blood supply
- Minimization of soft tissue stripping and devascularization
- Respect for the surrounding soft tissue envelope
-
Reduction of surgical trauma and inflammatory response
-
Indirect Reduction Techniques:
- Ligamentotaxis principles using traction
- Joystick manipulation with percutaneous tools
- Use of reduction aids (distraction devices, external fixators)
- Restoration of length, alignment, and rotation without direct fracture exposure
-
Acceptance of functional rather than anatomic reduction for certain fracture patterns
-
Stability Concepts:
-
Relative Stability Principle:
- Controlled micromotion stimulating callus formation
- Bridge plating across comminuted segments
- Load-sharing rather than load-bearing constructs
- Elastic fixation promoting secondary bone healing
-
Absolute Stability Requirements:
- Articular surface reconstruction
- Simple fracture patterns amenable to compression
- Situations requiring primary bone healing
-
Implant Selection Principles:
- Longer plates with fewer screws for diaphyseal fractures
- Locking technology reducing need for plate-bone contact
- Anatomically precontoured plates facilitating percutaneous insertion
- Specialized insertion handles and targeting devices
- Consideration of working length and screw density
Advantages and Limitations
- Biological Advantages:
- Preservation of fracture biology and blood supply
- Reduced surgical trauma and inflammatory response
- Decreased periosteal stripping and devascularization
- Potential for enhanced callus formation
-
Reduced risk of infection and wound complications
-
Clinical Advantages:
- Reduced operative time in experienced hands
- Decreased blood loss
- Lower infection rates
- Reduced postoperative pain
- Earlier mobilization potential
-
Improved cosmetic outcomes with smaller incisions
-
Limitations and Challenges:
- Steep learning curve
- Increased radiation exposure
- Limited direct visualization of the fracture
- Challenges in achieving reduction of certain fracture patterns
- Potential for malreduction or malrotation
-
Technical complexity requiring specialized training
-
Contraindications and Cautions:
- Severely displaced intra-articular fractures requiring direct visualization
- Pathological fractures requiring tumor removal
- Infected fractures requiring debridement
- Situations where anatomic reduction is mandatory
- Severe osteoporosis limiting percutaneous reduction capabilities
- Limited fluoroscopic visualization due to body habitus or positioning constraints
Minimally Invasive Plate Osteosynthesis (MIPO)
Technical Principles and Execution
- Preoperative Planning:
- Fracture pattern analysis and classification
- Determination of appropriate plate length and position
- Identification of key reduction parameters
- Planning of incision locations and approach
- Consideration of patient positioning and imaging requirements
-
Template selection for precontoured plates
-
Surgical Approach Considerations:
- Strategic placement of small incisions (typically proximal and distal to fracture)
- Safe corridors for plate insertion
- Protection of neurovascular structures
- Creation of submuscular or epiperiosteal tunnels
-
Preservation of soft tissue attachments to fracture fragments
-
Reduction Techniques:
- External manipulation and traction
- Use of distraction devices or temporary external fixation
- Percutaneous clamps and reduction forceps
- Joystick technique using Schanz pins or K-wires
- Articulating reduction instruments
-
Sequential reduction of key fragments
-
Plate Insertion and Fixation:
- Creation of submuscular or epiperiosteal tunnel
- Use of specialized insertion handles
- Fluoroscopic confirmation of plate position
- Provisional fixation with K-wires
- Sequential screw insertion using targeting guides
- Confirmation of reduction and fixation stability
Anatomic-Specific MIPO Techniques
- Femoral MIPO Applications:
-
Distal Femur:
- Lateral approach with submuscular plate placement
- Articular block reconstruction when needed
- Indirect reduction of metaphyseal component
- Use of precontoured distal femoral locking plates
- Technical pearls for avoiding malreduction
-
Femoral Shaft:
- Lateral submuscular approach
- Reduction techniques with traction
- Comparison with antegrade and retrograde nailing
- Indications and contraindications
-
Proximal Femur:
- Subtrochanteric fracture applications
- Reduction techniques for maintaining neck-shaft angle
- Specialized implant considerations
-
Tibial MIPO Applications:
-
Proximal Tibia:
- Anterolateral and medial approaches
- Articular reduction techniques when needed
- Submuscular plate placement
- Specialized reduction tools for plateau fractures
- Posteromedial and posterolateral approaches
-
Tibial Shaft:
- Medial MIPO technique
- Anterolateral approach considerations
- Comparison with intramedullary nailing
- Reduction strategies for maintaining alignment
-
Distal Tibia:
- Medial and anterolateral approaches
- Pilon fracture management
- Staged protocols for high-energy injuries
- Fibular fixation considerations
-
Upper Extremity MIPO Applications:
-
Humeral Shaft:
- Anterolateral and posterior approaches
- Radial nerve considerations
- Reduction techniques and pitfalls
- Comparison with intramedullary nailing
-
Proximal Humerus:
- Deltoid-splitting approach
- Reduction techniques for tuberosities
- Plate positioning to avoid impingement
- Rotator cuff considerations
-
Forearm:
- Limited applications for specific fracture patterns
- Technical considerations and limitations
- Comparison with traditional ORIF
-
Other Applications:
-
Clavicle:
- Superior and anterior plate positioning
- Neurovascular considerations
- Reduction techniques and outcomes
-
Calcaneus:
- Sinus tarsi approach
- Limited visualization techniques
- Specialized reduction instruments
-
Pelvic and Acetabular:
- Limited applications for specific patterns
- Specialized approaches and techniques
- Navigation assistance
Clinical Outcomes and Evidence
- Distal Femoral Fractures:
- Union rates (typically 90-95%)
- Functional outcomes (Knee Society Scores)
- Comparison with traditional ORIF
- Complication profiles (malunion, nonunion)
- Return to function timelines
-
Patient satisfaction measures
-
Tibial Fractures:
-
Proximal Tibia:
- Articular reduction quality assessment
- Functional outcomes (Lysholm, KOOS)
- Comparison with traditional approaches
- Complication rates (infection, malalignment)
- Return to activities and weight-bearing
-
Tibial Shaft:
- Union rates compared to IMN and traditional ORIF
- Alignment outcomes
- Infection rates in closed and open fractures
- Functional recovery timelines
- Cost-effectiveness analysis
-
Upper Extremity Outcomes:
- Humeral shaft union rates and times
- Functional outcomes (DASH, Constant scores)
- Radial nerve palsy incidence
- Comparison with other fixation methods
- Patient satisfaction and cosmetic results
-
Return to work and activities
-
Systematic Reviews and Meta-analyses:
- Pooled data on infection rates
- Comparative union times
- Functional outcome aggregation
- Complication profile analysis
- Evidence-based recommendations
- Identification of knowledge gaps
Complications and Their Management
- Reduction-Related Complications:
- Malalignment (varus/valgus, procurvatum/recurvatum)
- Malrotation
- Prevention strategies and intraoperative assessment
- Management options when identified
-
Outcomes after correction
-
Fixation-Related Complications:
- Implant failure mechanisms
- Screw pullout or breakage
- Plate breakage
- Prevention through proper technique
- Management strategies
-
Revision options
-
Biological Complications:
- Nonunion development
- Delayed union
- Contributing factors in MIPO
- Prevention strategies
- Management approaches
-
Outcomes after intervention
-
Technical Complications:
- Iatrogenic fractures during insertion
- Neurovascular injury
- Soft tissue impingement
- Prevention through proper technique
- Recognition and management
- Learning curve considerations
Minimally Invasive Intramedullary Nailing
Principles and Evolution
- Historical Development:
- Küntscher’s original closed nailing concept
- Evolution from solid to cannulated nails
- Development of interlocking capabilities
- Introduction of reaming techniques
-
Modern design features enhancing minimally invasive application
-
Biological Advantages:
- Preservation of fracture hematoma
- Minimal disruption of periosteal blood supply
- Load-sharing mechanical environment
- Promotion of secondary bone healing
-
Reduced soft tissue dissection
-
Biomechanical Principles:
- Intramedullary position providing optimal mechanical axis
- Load-sharing rather than load-bearing
- Multi-planar stability through interlocking
- Working length concepts
-
Strain environment conducive to callus formation
-
Modern Nail Design Features:
- Anatomic nail designs for specific bones
- Multiple locking options for rotational control
- Variable entry point options
- Enhanced targeting systems
- Specialized designs for proximal and distal fractures
Technical Considerations
- Preoperative Planning:
- Fracture pattern assessment
- Determination of nail diameter and length
- Entry point planning
- Consideration of reaming vs. unreamed technique
- Positioning and setup requirements
-
Reduction strategy development
-
Reduction Techniques:
- Closed manual reduction
- Traction table utilization
- Percutaneous reduction tools
- Limited open reduction when necessary
- Blocking screws for maintaining reduction
-
Poller screw techniques for metaphyseal control
-
Entry Point Considerations:
- Anatomic entry points by bone
- Soft tissue protection strategies
- Fluoroscopic guidance techniques
- Prevention of iatrogenic comminution
-
Management of difficult entry points
-
Locking Considerations:
- Static vs. dynamic locking decisions
- Distal targeting techniques
- Free-hand vs. guided locking
- Near-cortex locking options
- Advanced locking mechanisms
Anatomic-Specific Applications
- Femoral Nailing:
-
Antegrade Femoral Nailing:
- Piriformis vs. trochanteric entry points
- Reduction techniques for subtrochanteric extension
- Management of proximal and distal fractures
- Recon nail applications for neck/shaft combinations
-
Retrograde Femoral Nailing:
- Entry point precision requirements
- Applications in floating knee
- Distal fracture management
- Periprosthetic fracture applications
-
Tibial Nailing:
- Suprapatellar vs. infrapatellar approaches
- Semiextended positioning advantages
- Proximal and distal fracture management
- Blocking screw techniques
-
Fibular fixation considerations
-
Humeral Nailing:
- Antegrade approaches (lateral vs. anterior)
- Retrograde techniques
- Rotator cuff considerations
- Reduction challenges and solutions
-
Comparison with plate fixation
-
Specialized Applications:
- Forearm nailing techniques
- Clavicular intramedullary fixation
- Pediatric flexible nailing
- Small bone applications (metacarpals, metatarsals)
- Arthrodesis techniques
Clinical Outcomes and Evidence
- Femoral Fractures:
- Union rates by fracture location
- Functional outcomes and return to activities
- Comparison with plate fixation
- Complication profiles
-
Long-term outcomes and implant removal
-
Tibial Fractures:
- Union rates in closed and open fractures
- Functional outcomes and return to activities
- Anterior knee pain incidence with different approaches
- Comparison with plate fixation
-
Outcomes in proximal and distal fractures
-
Upper Extremity Applications:
- Humeral shaft union rates
- Shoulder and elbow function after nailing
- Comparison with plate fixation
- Rotator cuff morbidity assessment
-
Patient satisfaction measures
-
Meta-analyses and Systematic Reviews:
- Comparative effectiveness data
- Pooled complication rates
- Union time comparisons
- Functional outcome aggregation
- Evidence-based recommendations
Complications and Their Management
- Entry Point Complications:
- Iatrogenic fractures
- Soft tissue damage (rotator cuff, patellar tendon)
- Malposition leading to malalignment
- Prevention strategies
-
Management approaches
-
Reduction-Related Complications:
- Malalignment
- Distraction at fracture site
- Rotational malalignment
- Prevention through proper technique
-
Assessment methods and correction
-
Hardware-Related Complications:
- Nail breakage
- Locking screw failure
- Prominent hardware
- Prevention strategies
-
Management options
-
Biological Complications:
- Nonunion development
- Infection
- Compartment syndrome
- Fat embolism syndrome
- Prevention and management strategies
Percutaneous Fracture Fixation Techniques
Cannulated Screw Fixation
- Principles and Applications:
- Compression screw principles
- Lag screw technique through cannulated systems
- Guide wire-based precision
- Minimally invasive application methods
-
Appropriate fracture pattern selection
-
Technical Considerations:
- Guide wire placement techniques
- Fluoroscopic visualization methods
- Screw selection principles
- Compression achievement
-
Multiple screw configurations
-
Common Applications:
-
Hip Fractures:
- Femoral neck fractures
- Percutaneous techniques
- Outcomes and complications
-
Articular Fractures:
- Scaphoid fractures
- Ankle fractures
- Tibial plateau fractures
- Radial head fractures
-
Pediatric Applications:
- Physeal fractures
- Technical considerations in growing bone
- Outcomes and growth disturbance risk
-
Outcomes and Complications:
- Union rates by fracture type
- Functional outcomes
- Complication profiles
- Comparison with open techniques
- Long-term results and hardware removal
Percutaneous Pinning Techniques
- Principles and Indications:
- Temporary vs. definitive fixation
- Minimal soft tissue disruption
- Applications in periarticular fractures
- Pediatric fracture applications
-
Supplemental fixation concepts
-
Technical Considerations:
- Pin placement techniques
- Crossing patterns for stability
- Entry point selection
- Soft tissue protection
-
Pin care protocols
-
Common Applications:
- Distal radius fractures
- Metacarpal and phalangeal fractures
- Pediatric supracondylar humeral fractures
- Supplemental fixation in complex fractures
-
Temporary bridging in staged protocols
-
Outcomes and Complications:
- Union rates and times
- Functional outcomes
- Pin tract infection rates
- Loss of reduction incidence
- Comparison with alternative fixation
Percutaneous Fragment-Specific Fixation
- Principles and Development:
- Targeted fixation of specific fragments
- Minimally invasive application
- Specialized implant systems
- Anatomic-specific designs
-
Combined approaches with standard plating
-
Technical Considerations:
- Fragment identification and access
- Reduction techniques
- Specialized instrumentation
- Fluoroscopic guidance
-
Fixation stability assessment
-
Common Applications:
- Distal radius fragment-specific systems
- Tibial plateau fracture applications
- Calcaneal fracture techniques
- Acetabular fracture adjuncts
-
Pelvic fracture applications
-
Outcomes and Evidence:
- Reduction quality assessment
- Functional outcomes
- Complication profiles
- Comparison with standard techniques
- Cost-effectiveness considerations
Advanced Technologies in Minimally Invasive Fracture Fixation
Intraoperative Imaging Advancements
- Advanced Fluoroscopy:
- 3D fluoroscopy capabilities
- Cone-beam CT applications
- Radiation reduction technologies
- Image enhancement features
-
Integration with navigation
-
Intraoperative CT:
- O-arm and similar technologies
- Applications in complex fractures
- Verification of reduction and hardware position
- Workflow integration
-
Radiation considerations
-
Ultrasound Applications:
- Fracture reduction assessment
- Soft tissue evaluation
- Hardware positioning guidance
- Radiation-free monitoring
-
Emerging applications
-
Augmented Reality and Projection:
- Skin projection technologies
- Augmented fluoroscopy
- Heads-up display systems
- Clinical applications and limitations
- Future directions
Navigation and Robotics
- Navigation Systems:
- Optical tracking technologies
- Electromagnetic tracking systems
- Registration techniques
- Applications in fracture surgery
-
Accuracy and workflow considerations
-
Patient-Specific Instrumentation:
- 3D planning software
- Custom guide fabrication
- Applications in complex fractures
- Accuracy and outcomes
-
Cost and accessibility considerations
-
Robotic-Assisted Fracture Surgery:
- Current systems and capabilities
- Applications in trauma
- Accuracy studies
- Workflow integration
-
Learning curve considerations
-
Artificial Intelligence Applications:
- Fracture detection and classification
- Reduction quality assessment
- Surgical planning assistance
- Intraoperative decision support
- Future directions and limitations
Specialized Reduction Tools
- Percutaneous Reduction Forceps:
- Design evolution
- Applications by fracture type
- Technical tips for effective use
- Limitations and complications
-
Outcomes with specialized tools
-
Joystick Reduction Techniques:
- Schanz pin applications
- Specialized handle systems
- Technical execution
- Applications by fracture pattern
-
Integration with fixation methods
-
Distraction Systems:
- External fixator-assisted reduction
- Specialized distraction tools
- Applications in periarticular fractures
- Technique tips and pearls
-
Outcomes and complications
-
Balloon Technologies:
- Inflatable reduction systems
- Applications in metaphyseal fractures
- Technical considerations
- Outcomes and evidence
- Future directions
Emerging Minimally Invasive Technologies
- Expandable Implants:
- Intramedullary devices
- Vertebral body applications
- Metaphyseal fracture solutions
- Technical considerations
-
Early clinical evidence
-
Bioresorbable Implant Systems:
- Material properties and degradation
- Applications in minimally invasive fixation
- Advantages and limitations
- Clinical evidence and outcomes
-
Future directions
-
Injectable Bone Substitutes:
- Percutaneous delivery systems
- Applications in void filling
- Augmentation of fixation
- Clinical outcomes
-
Combination with standard fixation
-
Adhesive Technologies:
- Bone glues and cements
- Applications in fracture fixation
- Minimally invasive delivery
- Combination with standard implants
- Evidence and outcomes
Clinical Decision Making and Future Directions
Patient Selection and Indications
- Fracture Pattern Considerations:
- Ideal patterns for minimally invasive approaches
- Relative and absolute contraindications
- Decision algorithms by fracture type
- Conversion criteria to open techniques
-
Evidence-based selection guidelines
-
Patient Factors:
- Age and bone quality considerations
- Soft tissue condition assessment
- Comorbidity impact on decision making
- Functional demands and expectations
-
Compliance considerations
-
Surgeon Factors:
- Learning curve considerations
- Volume-outcome relationships
- Training requirements
- Institutional support needs
-
Ethical considerations in adoption
-
Resource Considerations:
- Equipment requirements
- Cost-effectiveness analysis
- Operating room setup needs
- Imaging requirements
- Team training needs
Training and Learning Curve
- Learning Curve Assessment:
- Procedure-specific learning curves
- Volume thresholds for proficiency
- Complication rates during learning phase
- Strategies for reducing learning curve impact
-
Institutional experience considerations
-
Training Methodologies:
- Simulation-based training
- Cadaveric laboratories
- Graduated responsibility approaches
- Mentorship models
-
Assessment tools for competency
-
Implementation Strategies:
- Institutional adoption approaches
- Team training considerations
- Case selection for early experience
- Monitoring and quality improvement
-
Complication management protocols
-
Continuing Education:
- Maintaining skills with evolving technology
- Keeping current with evidence
- Advanced training opportunities
- Peer learning and collaboration
- Quality improvement initiatives
Future Directions and Innovations
- Biological Enhancement Integration:
- Growth factor delivery systems
- Cell-based therapies
- Gene therapy approaches
- Bioactive implant coatings
-
Minimally invasive delivery systems
-
Advanced Materials Development:
- Smart materials with adaptive properties
- Bioabsorbable implant evolution
- Composite materials with enhanced properties
- Infection-resistant surfaces
-
Osseointegration-promoting technologies
-
Imaging and Navigation Evolution:
- Real-time navigation advancements
- Augmented reality applications
- Radiation-free tracking systems
- Artificial intelligence integration
-
Automated reduction assistance
-
Personalized Fracture Care:
- Patient-specific implant design
- Fracture pattern-specific constructs
- Bone quality-based fixation strategies
- Outcome prediction models
- Individualized rehabilitation protocols
Conclusion
Minimally invasive fracture fixation represents a significant evolution in orthopedic trauma care, shifting focus from absolute mechanical stability achieved through extensive surgical approaches to biological fixation that preserves the fracture environment while providing adequate stability for healing. This approach recognizes that successful fracture management requires balancing mechanical and biological factors, with the preservation of blood supply, soft tissue integrity, and fracture hematoma being as important as the mechanical construct itself.
The development of specialized implants, instruments, and techniques has expanded the applications of minimally invasive fixation across virtually all anatomical regions and fracture types. From percutaneous plating of periarticular fractures to advanced intramedullary nailing systems, these techniques have demonstrated advantages including reduced surgical trauma, decreased infection rates, faster healing times, and improved functional outcomes in appropriately selected cases.
The successful implementation of minimally invasive fracture fixation requires a comprehensive understanding of fracture biology, indirect reduction principles, and implant biomechanics. It demands technical proficiency with fluoroscopic imaging, specialized instrumentation, and the ability to achieve reduction without direct visualization of the fracture. The learning curve associated with these techniques presents challenges for training and implementation, necessitating structured educational approaches and mentorship.
While minimally invasive techniques offer significant advantages in many fracture scenarios, they are not universally applicable. The appropriate selection of cases, understanding of limitations, and recognition of situations where more traditional approaches may be preferable are essential for optimizing outcomes. The decision-making process must consider fracture pattern, patient factors, surgeon experience, and available resources.
The future of minimally invasive fracture fixation lies in continued technological innovation, including advanced imaging and navigation systems, specialized reduction tools, novel implant designs, and biological enhancement strategies. The integration of robotics, artificial intelligence, and patient-specific approaches promises to further refine these techniques, potentially expanding their applications while reducing complications and improving outcomes.
In conclusion, minimally invasive fracture fixation represents a paradigm shift in orthopedic trauma care that has transformed the approach to many fracture types. By balancing biological preservation with mechanical stability requirements, these techniques offer significant advantages in appropriately selected cases. Continued research, technological innovation, and refinement of surgical techniques will further enhance the capabilities and outcomes of minimally invasive fracture fixation, ultimately improving patient care in orthopedic trauma.
Medical Disclaimer: The information provided in this article is for educational purposes only and should not be considered as medical advice. Always consult with a qualified healthcare professional for diagnosis and treatment of medical conditions. Invamed provides this information to enhance understanding of medical technologies but does not endorse specific treatment approaches outside the approved indications for its devices.