Filler สารอุดหลอดเลือดที่ใช้ไซยาโนอะคริเลต

Filler สารอุดหลอดเลือดที่ใช้ไซยาโนอะคริเลต

เอ ไซยาโนอะคริเลต กาวอุดหลอดเลือดสำหรับ หลอดเลือด หรือ เอวีเอ็ม การอุดตัน, การเสนอ เร็ว การเกิดพอลิเมอร์เมื่อสัมผัสกับเลือด ช่วยให้ปิดผนึกภาชนะได้อย่างมั่นคงและมีสิ่งแปลกปลอมน้อยที่สุด

ข้อมูล

Rapid and Reliable Embolization for Critical Moments

  • The Filler Cyanoacrylate-Based Embolization Agent is distinguished by its rapid polymerization and targeted application, ensuring immediate and reliable vessel occlusion. 
  • Filler works by causing an inflammatory reaction over the endothelium of the target vein upon the injection of the polymer and simultaneous pressure application.

Secure Occlusion, Superior Outcomes

  • Its high-viscosity formulation and compatibility with standard catheters enhance control during application, minimizing the risk of non-target embolization.
  • Filler was developed for the treatment of peripheral and neurovascular, including arteriovenous malformations and hypervascular tumors by a simple polymerization method.
  • Small amounts of polymer were delivered endovenous and pressure of up to 2-3 minutes to applied for total closure.

CAN BE
PERFORMED
SAFELY

Filler: Precision Embolization, Promising Results

Designed for biocompatibility, Filler minimizes inflammatory responses post-embolization, promoting patient safety and recovery. Choose Filler for a cutting-edge embolization solution that delivers superior outcomes and sets the standard in vascular care.

  • Agent Type: Cyanoacrylate-based embolization agent.
  • Composition: A high-viscosity liquid embolic agent, consisting of cyanoacrylate, designed for controlled and targeted embolization.
  • Mechanism of Action: Rapid polymerization upon contact with ionic substances such as blood, leading to instant vessel occlusion.
  • Indications: Suitable for arteriovenous malformations, gastrointestinal bleeding, and pre-surgical embolization.
  • Application: Delivered through standard catheters, allowing for precise application and minimization of non-target embolization.
  • Biocompatibility: Designed to be biocompatible and minimize inflammatory responses post-embolization.

FAST
EFFECTIVE
& EASY

Filler Cyanoacrylate-Based Embolization Agent stands out as a cutting-edge solution for targeted and rapid vascular occlusion. Its high-viscosity liquid form, comprised of cyanoacrylate, is expertly designed to ensure controlled application and immediate results.

Upon contact with ionic substances such as blood, Filler rapidly polymerizes, leading to instant and durable vessel occlusion. This makes it an ideal choice for critical applications such as arteriovenous malformations, gastrointestinal bleeding, and pre-surgical embolization. Its delivery through standard catheters ensures precise application, reducing the risk of non-target embolization and enhancing procedural success.

  • Neuro Aneurysms and AVMs
  • Abdominal Aneurysms, Endoleaks
  • Neurovascular & Peripheral Aneurysms and AVMs
  • Short procedure procedure time.
  • Mix with lipiodol for radiopacity

Filler is delivered through a microcatheter into the AVM under fluoroscopic control.

Filler immediately forms a skin as the polymeric embolus solidifies from the outside to the inside, while traveling more distally in the vessel.

Type 2 endoleak from lumbar arteries. (A) Computed tomography (CT) scan in the procubitus position shows posterior opacification of the periprosthetic aneurysmal sac (nidus). (B) Embolization of the endoleak center with a microcatheter under CT guidance until nidus opacification is complete.

ข้อมูลจำเพาะผลิตภัณฑ์

ข้อมูลจำเพาะ รายละเอียด / มูลค่า
ชื่อสินค้า Filler Cyanoacrylate Embolization Agent
วัตถุประสงค์การใช้ Embolization of AVMs, fistulas, varices, or other lesions requiring permanent vascular occlusion
Composition n-Butyl or n-Hexyl cyanoacrylate formulation, polymerizes rapidly upon contact with blood/tissue
Polymerization Mechanism Instant polymerization triggered by ionic/aqueous environment
Delivery Method Via microcatheter (coaxial with DMSO or compatible flushing agent, if needed)
ความไวแสง May require added radiopaque contrast (e.g., Lipiodol) for fluoroscopic visibility
Viscosity Low to medium (check final specs), allowing controlled injection time
ความปลอดเชื้อ ปลอดเชื้อ ใช้ครั้งเดียว
อายุการเก็บรักษา ~2–3 ปี ที่อุณหภูมิ 15–25 °C ในบรรจุภัณฑ์ที่ปิดสนิท
ข้อบ่งชี้ทางคลินิก Neurovascular or peripheral AVM occlusion, gastrointestinal bleeders, variceal management, certain tumor devascularizations
ข้อห้ามใช้ Vessel lumens too small for catheter access, potential risk if accidental nontarget injection, known allergy to cyanoacrylates

การสั่งซื้อและเมทริกซ์ขนาด

Cyanoacrylate Concentration (%) Vial Volume (mL) Recommended Mixing Ratio รหัสสินค้า หมายเหตุ
33 1.0 1:1 with radiopaque agent FIL-33-1.0-1:1 Lower concentration, slower polymerization, suitable for distal lesions
33 2.0 1:1 FIL-33-2.0-1:1 Larger vial, same concentration
50 1.0 1:0.5 FIL-50-1.0-1:0.5 Faster set time, moderate volume
50 2.0 1:0.5 FIL-50-2.0-1:0.5 Larger volume for multiple feeders
67 1.0 1:0.25 FIL-67-1.0-1:0.25 High concentration, rapid polymerization for high-flow lesions
67 2.0 1:0.25 FIL-67-2.0-1:0.25 Maximum control in large or complex AVMs

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