Filler Cyanoacrylate-Based Embolization Agent
A cyanoacrylate embolic adhesive for vascular or AVM occlusion, offering quick polymerization upon contact with blood, ensuring stable vessel seal and minimal artifact.
Rapid and Reliable Embolization for Critical Moments
- The Filler Cyanoacrylate-Based Embolization Agent is distinguished by its rapid polymerization and targeted application, ensuring immediate and reliable vessel occlusion.
- Filler works by causing an inflammatory reaction over the endothelium of the target vein upon the injection of the polymer and simultaneous pressure application.
Secure Occlusion, Superior Outcomes
- Its high-viscosity formulation and compatibility with standard catheters enhance control during application, minimizing the risk of non-target embolization.
- Filler was developed for the treatment of peripheral and neurovascular, including arteriovenous malformations and hypervascular tumors by a simple polymerization method.
- Small amounts of polymer were delivered endovenous and pressure of up to 2-3 minutes to applied for total closure.

CAN BE
PERFORMED
SAFELY
Filler: Precision Embolization, Promising Results
Designed for biocompatibility, Filler minimizes inflammatory responses post-embolization, promoting patient safety and recovery. Choose Filler for a cutting-edge embolization solution that delivers superior outcomes and sets the standard in vascular care.
- Agent Type: Cyanoacrylate-based embolization agent.
- Composition: A high-viscosity liquid embolic agent, consisting of cyanoacrylate, designed for controlled and targeted embolization.
- Mechanism of Action: Rapid polymerization upon contact with ionic substances such as blood, leading to instant vessel occlusion.
- Indications: Suitable for arteriovenous malformations, gastrointestinal bleeding, and pre-surgical embolization.
- Application: Delivered through standard catheters, allowing for precise application and minimization of non-target embolization.
- Biocompatibility: Designed to be biocompatible and minimize inflammatory responses post-embolization.
FAST
EFFECTIVE
& EASY
Filler Cyanoacrylate-Based Embolization Agent stands out as a cutting-edge solution for targeted and rapid vascular occlusion. Its high-viscosity liquid form, comprised of cyanoacrylate, is expertly designed to ensure controlled application and immediate results.
Upon contact with ionic substances such as blood, Filler rapidly polymerizes, leading to instant and durable vessel occlusion. This makes it an ideal choice for critical applications such as arteriovenous malformations, gastrointestinal bleeding, and pre-surgical embolization. Its delivery through standard catheters ensures precise application, reducing the risk of non-target embolization and enhancing procedural success.

- Neuro Aneurysms and AVMs
- Abdominal Aneurysms, Endoleaks
- Neurovascular & Peripheral Aneurysms and AVMs
- Short procedure procedure time.
- Mix with lipiodol for radiopacity
Filler is delivered through a microcatheter into the AVM under fluoroscopic control.
Filler immediately forms a skin as the polymeric embolus solidifies from the outside to the inside, while traveling more distally in the vessel.
Type 2 endoleak from lumbar arteries. (A) Computed tomography (CT) scan in the procubitus position shows posterior opacification of the periprosthetic aneurysmal sac (nidus). (B) Embolization of the endoleak center with a microcatheter under CT guidance until nidus opacification is complete.
Product Specifications
Specification | Detail / Value |
Product Name | Filler Cyanoacrylate Embolization Agent |
Intended Use | Embolization of AVMs, fistulas, varices, or other lesions requiring permanent vascular occlusion |
Composition | n-Butyl or n-Hexyl cyanoacrylate formulation, polymerizes rapidly upon contact with blood/tissue |
Polymerization Mechanism | Instant polymerization triggered by ionic/aqueous environment |
Delivery Method | Via microcatheter (coaxial with DMSO or compatible flushing agent, if needed) |
Radiopacity | May require added radiopaque contrast (e.g., Lipiodol) for fluoroscopic visibility |
Viscosity | Low to medium (check final specs), allowing controlled injection time |
Sterility | Sterile, Single Use |
Shelf Life | ~2–3 years at 15–25 °C in sealed packaging |
Clinical Indications | Neurovascular or peripheral AVM occlusion, gastrointestinal bleeders, variceal management, certain tumor devascularizations |
Contraindications | Vessel lumens too small for catheter access, potential risk if accidental nontarget injection, known allergy to cyanoacrylates |
Ordering & Size Matrix
Cyanoacrylate Concentration (%) | Vial Volume (mL) | Recommended Mixing Ratio | Product Code | Notes |
33 | 1.0 | 1:1 with radiopaque agent | FIL-33-1.0-1:1 | Lower concentration, slower polymerization, suitable for distal lesions |
33 | 2.0 | 1:1 | FIL-33-2.0-1:1 | Larger vial, same concentration |
50 | 1.0 | 1:0.5 | FIL-50-1.0-1:0.5 | Faster set time, moderate volume |
50 | 2.0 | 1:0.5 | FIL-50-2.0-1:0.5 | Larger volume for multiple feeders |
67 | 1.0 | 1:0.25 | FIL-67-1.0-1:0.25 | High concentration, rapid polymerization for high-flow lesions |
67 | 2.0 | 1:0.25 | FIL-67-2.0-1:0.25 | Maximum control in large or complex AVMs |
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