Libro Non-Adhesive Embolization Agent: EVOH, DMSO and Tantalum

Libro Non-Adhesive Embolization Agent: EVOH, DMSO and Tantalum

A non-adhesive liquid embolic system combining EVOH, DMSO, and tantalum for controlled devascularization of AVMs or tumor feeding vessels, ensuring precise deployment without permanent vessel adherence.

Information

Advanced Formula and Precision in Flow Control

  • Composition: A unique blend of EVOH (Ethylene Vinyl Alcohol Copolymer), DMSO (Dimethyl Sulfoxide), and Tantalum.
  • Non-Adhesive Formula: Ensures controlled and precise embolization, reducing the risk of non-target embolization.
  • High Radiopacity: Tantalum provides excellent visibility under imaging, ensuring accurate deployment.

Optimal Outcomes for 3 Different Formulas

  • Its non-adhesive nature ensures stable and cohesive embolus formation without compromising the vessel walls.
  • Biocompatible: The materials used are safe and well-tolerated by the body.
  • Versatile Use: Suitable for a wide range of neurovascular applications.
  • Stable and Consistent: Provides reliable performance for every procedure.

Libro: Setting the Standard in Controlled Vascular Occlusion

The agent’s solubility in DMSO enables delivery through microcatheters, ensuring targeted application and reducing the risk of non-target embolization. The inclusion of Tantalum powder enhances radiopacity, allowing for real-time monitoring and precise placement, further ensuring procedural success.

Libro Non-Adhesive Embolization Agent represents a paradigm shift in vascular occlusion, combining Ethylene Vinyl Alcohol Copolymer (EVOH), Dimethyl Sulfoxide (DMSO), and Tantalum powder to deliver a state-of-the-art solution.

This unique blend ensures a stable and cohesive embolus formation upon contact with blood, while maintaining non-adhesive properties to preserve the integrity of the vessel walls. Libro’s EVOH component guarantees durability and biocompatibility, ensuring long-term patient safety.

The solubility in DMSO allows for delivery through microcatheters, enhancing the precision of application and minimizing the risk of non-target embolization. Additionally, the inclusion of Tantalum powder ensures superior radiopacity, providing clinicians with real-time monitoring capabilities and ensuring precise placement during procedures.

Choose Libro for a reliable, non-adhesive, and precisely controllable embolization agent, setting new standards in patient care and procedural success.

Libro is a non-adhesive liquid embolic agent comprised of EVOH (ethylene vinyl alcohol) copolymer dissolved in DMSO (dimethyl sulfoxide), and suspended micronized tantalum powder to provide contrast for visualization under fluoroscopy.

EVOH Base (Ethylene Vinyl Alcohol Copolymer)
  • Stable Embolic Matrix: Once injected, the EVOH solution solidifies upon contact with blood or aqueous medium, forming an occlusive cast within the targeted vasculature.
  • Non-Adhesive: Minimizes risk of catheter entrapment, enabling smoother microcatheter withdrawal post-embolization.
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  • Uniform Dispersion: Maintains the EVOH in a liquid state until injection, allowing for precise and controlled delivery.
  • Gradual Precipitation: The polymer solidifies from the outer surface inward, helping operators monitor and fine-tune deposition patterns.
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  • Integrated Tantalum Powder (or similar radiopaque agent) ensures fluoroscopic visibility, enabling real-time feedback on embolic material positioning.

Product Specifications

Specification Detail / Value
Product Name Libro Non-Adhesive Embolization Agent (EVOH-based liquid embolic with DMSO solvent and tantalum for radiopacity)
Intended Use Embolization of cerebral or peripheral arteriovenous malformations (AVMs), hypervascular tumors, or similar lesions
Composition EVOH (ethylene vinyl alcohol) copolymer, DMSO solvent, tantalum powder for radiopacity
Viscosity Range Varies by concentration of EVOH (low, medium, high viscosity)
Polymerization Mechanism Precipitation in blood upon DMSO diffusion, forming a non-adhesive solid cast in the lesion
Delivery Method Via microcatheter compatible with DMSO (e.g., 1.5–1.8F or 2.0–2.3F ID)
Radiopacity Tantalum provides fluoroscopic visibility throughout injection and polymerization
Sterility Sterile, Single Use
Shelf Life ~2–3 years if stored at 15–25 °C in sealed packaging
Clinical Indications AVM occlusion, tumor devascularization, dural AVFs, select peripheral or neurovascular lesions
Contraindications Vessels too small for microcatheter passage, high-flow fistulas (might require different approach), known DMSO allergy

Ordering & Size Matrix

Viscosity Level EVOH Concentration (%) Tantalum Content (%) Vial Volume (mL) Product Code Notes
Low 6 25 1.0 LBR-L-6-25-1.0 Lower viscosity, deeper penetration into fine feeders
Low 6 25 1.5 LBR-L-6-25-1.5 Slightly larger volume, same concentration
Medium 8 25 1.0 LBR-M-8-25-1.0 Balanced viscosity for moderate AVMs
Medium 8 25 1.5 LBR-M-8-25-1.5 Additional volume option
High 10 30 1.0 LBR-H-10-30-1.0 More viscous agent for larger or high-flow lesions
High 10 30 1.5 LBR-H-10-30-1.5 Greater volume for extensive devascularization

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